MSC 2022 : Bioengineering Special Issue: Mesenchymal Stem Cells in Regenerative Medicine

Dear Colleagues,

I would like to cordially invite you to submit a research/review paper to the Special Issue “Mesenchymal Stem Cells” (the open access journal Bioengineering (ISSN 2306-5354)). The Mesenchymal Stem Cells (MSC) were discovered in the sixties of the 20th century. MSCs are situated in almost all organs and tissues of the human body. For practical purposes they are isolated and ex vivo expanded mainly from two main sources - from the bone marrow and fat tissue. Their expansion and isolation is rather simple and doesn’t require any sophisticated equipment. For decades they were used in regenerative medicine to treat previously “untreatable”. Nevertheless, we do need rules and data which are clear and without doubts. We need to follow “good biological practice” i.e. to work in the terms of real biology. The administrative rules should follow the biological laws and not vice versa. One needs to be careful not to blindly apply data obtained on rodents to humans. The gap between species is too bright. We need to solve other fundamental questions: Should the source of MSC be allogeneic or autologous? Are the autologous MSC “ill” with the patient? Can the huge amounts of ex vivo expanded MSC overcome their “illness”? How about the immune system of the host after administration of allogeneic MSC? And finally – what is the mechanism of action of repair and regeneration after MSCs administration?

Please contact Sophie Wang ([email protected]) if you have any questions.

Dr. Ján Lakota
Prof. Dr. Joaquim M. S. Cabral
Guest Editors