MDPI materials 2019 : Bone Biomaterials

Dear Colleagues,

Bone biomaterials are used for the reconstruction of degenerated or damaged parts of the musculo-skeletal system. Controlling cell–biomaterial interactions plays a vital role in influencing subsequent biological processes such as cell proliferation and differentiation. In the last few decades, a variety of bone biomaterials with different physicochemical properties have been developed and analyzed to optimize the process of bone regeneration. An ideal bone biomaterial should provide a suitable cell microenvironment for bone building. Therefore they should show controlled biodegradability, provide an osteoconductive matrix to induce vascularization, or supply osteoinductive factors to direct the osteogenic differentiation of cells. The speed of degradation should ideally be synchronized with bone regeneration to ensure bone maturation and sufficient stability at the interface. As a result, the newly formed bone has similar physicochemical and mechanical properties as the surrounding skeletal tissue. Clinical experience in recent years has shown that biomaterials containing important bone minerals enhance the stable anchorage of the implant in the surrounding bone. These chemical and biological requirements are met excellently by ceramic materials based on calcium orthophosphates and by bioactive glasses. Load-bearing metal implants like prostheses are coated with ceramic materials.

This Special Issue focuses on degradable calcium phosphate biomaterials for bone tissue engineering. Contributions on related topics are also welcome. Thus, we invite reviews and/or original papers reporting new results in the field of bone substitute development, including in vitro and in vivo analyses.

Prof. Dr. Anke Bernstein
Guest Editor

Keywords

bone biomaterial
calcium phosphate
degradation
biocompatibility
cell microenvironment

Submission steps:
1. Register via our system https://susy.mdpi.com/ and login;

2. Click "Submit to Special Issue" at: https://www.mdpi.com/journal/materials/special_issues/Bone_Biomaterial