iPSC 2022 : Bioengineering Special Issue: Pluripotent Stem Cell Biology and Engineering

Dear Colleagues,

Pluripotent stem cells have proven to be powerful tools in bioengineering due to their enormous potential regarding disease modelling, drug discovery and cell therapy. Strategies towards a more efficient and reliable recapitulation of embryonic development are still required, and this can be achieved through further study of pluripotency mechanisms and methods to direct pluripotent stem cells towards a specific fate.

By carefully controlling the culture microenvironment, either using biochemical or biophysical cues, in combination with different bioengineering approaches, either at a cellular, multicellular, and multiorgan levels, it will be possible to fully comprehend and recreate the embryonic development, accelerating the discovery of novel applications and strategies for human pluripotent stem cells and their derivatives. This includes high-throughput screening for efficient and personalized new drugs, platforms that provide a better understanding of disease mechanisms or even the development of robust cell therapy products.

This Special Issue aims to gather articles that highlight new possibilities towards Pluripotent Stem Cell Biology and Engineering, from cellular and biomaterial perspectives. We are welcoming original research articles, review articles and short communications.

Potential topics in this Special Issue include, but are not limited to, the following:

New tissue engineering strategies;
Genome editing of human pluripotent stem cells;
Disease modeling using human pluripotent stem cells;
Microenvironment control strategies;
Bioprinted cell-based models;
Biomimetic scaffold development;
Novel biomaterials used in preclinical or clinical studies;
Validation of drugs and compounds in 3D in vitro systems using human pluripotent stem cell-derived cells;
Organ-on-a-chip and body-on-a-chip platforms.

Please contact Sophie Wang ([email protected]) if you have any questions.

Dr. CLÁUDIA MIRANDA
Dr. Paola Sanjuan Alberte
Guest Editors