The 29th Mediterranean Conference on Control and Automation (MED 2021) will be held in hybrid mode (both in presence and online) on the 22-25 of June 2021 in Puglia, Italy. Puglia is an important economic center in Southern Italy and is well-recognized as a bridge between West and East that mirrors an increasingly multi-cultural, open, tolerant and friendly community, connecting people, individuals and businesses, from different countries and cultures. MED 2021 will focus on smart cities and smart systems and will include tutorials and workshops, a technical program of presentations, keynote lectures and social events. It offers a great opportunity for academics, researchers, and industrial players working in control and automation to network together, present research progress and address new challenges. The conference will include a wide range of topics on systems, automation, robotics and control including theory, hardware, software, communication technologies and applications to smart grids, intelligent buildings, smart mobility, healthcare, factory 4.0, cyber-physical systems, and more.