The 2021 IEEE Data Science & Learning Workshop (DSLW 2021), to be co-located with ICASSP 2021, will be held at the University of Toronto on June 05-06, 2021. The workshop is organized by the IEEE Signal Processing Society (supported by the SPS Data Science Initiative). It aims to bring together researchers in academia and industry to share the most recent and exciting advances in data science and learning theory and applications. The workshop provides a venue for innovative data science & learning studies in various academic disciplines, including signal processing, statistics, machine learning, data mining and computer vision. Both studies on theoretical and methodological foundations and application studies in different domains (e.g., health care, earth and environmental science, applied physics, finance and economics, intelligent manufacturing) are welcome.