The 12th International Conference on Information and Communication Systems (ICICS 2021) is a forum for scientists, engineers, and practitioners to present their latest research results, ideas, developments, and applications in all areas of Computer and Information Sciences. The topics that will be covered in the ICICS 2021 include, but are not limited to: Artificial Intelligence, Mobile Computing, Networking, Information Security and Cryptography, Intrusion Detection and Computer Forensics, Web Content Mining, Bioinformatics and IT Applications, Database Technology, Systems Integration, Information Systems Analysis and Specification, Communications, and Human-Computer Interaction.